工作團隊

孫瑜

學歷

1. 臺灣大學預防醫學研究所博士

2. 中國醫藥學院醫學系

經歷

1.臺大醫院神經部住院醫師

 

2.臺大醫院神經部總醫師

 

3.1997年恩主公醫院創院的臺大醫師群之一,服務至今

現職

1. 行天宮醫療志業醫療財團法人恩主公醫院-神經科-主任

2. 台大醫學院醫學系兼任助理教授

 

授課:台大醫學系: 中樞神經感染及病例討論; 台大復健學系(職能治療/物理治療): 神經科學

 

3.臺大醫院神經部兼任主治醫師

 

4.睡眠醫學會專科醫師甄審委員

 

5.台灣失智症學會學術組委員

專長

1. 失智症

2. 睡眠障礙

3. 一般神經醫學

學會/資格/其他

一、獲獎榮譽

1.2000 年臺灣神經醫學會壁報優秀論文獎.

2.第五屆 (2002年) 杜世彬博士紀念論文獎第一名.

3.2005 年臺灣腦中風醫學會論文獎第二名.

4.2008 年臺灣神經醫學會壁報優秀論文獎 -- 腦中風組.

5.2008 年指導住院醫師研究獲臺灣神經醫學會壁報優秀論文獎 -- 神經影像組

6.腦中風醫學會 PAD and Stroke 國際研討會論文獎第一名

 

二、近五年獲邀至國內外醫學會年會、國際或全國性專題學術演講

1.2012臺灣醫學會年會-失智症藥物預防與治療的新進展

2.2012韓國腦中風學會年會-International Guideline Review in 2nd Stroke prevention

3.2013 International Conference of Alzheimer’s Disease International-

4.Epidemiological Study of Dementia (Including Mild Cognitive Impairment) in Taiwan

5.2013台灣公共衛生學會年會-輕度認知功能障礙及失智症盛行率之全國性調查

6.2014社團法人台灣失智症協會、台灣臨床失智症學會-失智症流行病學調查之研究設計

7.2014臺灣醫學會春季學術演講會-糖尿病藥物的中風風險

8.2014台灣腦中風學會年會-High Risk of Stroke Patients with Peripheral Artery Disease in Taiwan

9.2014香港腦中風學會年會-The Efficacy and Safety of Cilostazol in Ischemic Stroke Patients with Peripheral Arterial Disease

10.2014台灣神經生理技術學會年會-Sleep related Neurologic Disorders

11.2016台灣腦中風學會年會-The Best and Worst Case Scenarios in the Stroke Prevention of Atrial Fibrillation

12.2017全球失智症報告-失智症健康照護路徑的成本

13.於國內外醫學會及國際研討會發表研究論文超過30篇

 

三、近五年參與國際性多國多中心或國內的臨床試驗擔任主持人或共同主持人

(一)臨床試驗研究計劃:

2.2011 Cilostazol用在缺血性腦中風病患合併周邊動脈疾病的療效與安全性 (SPAD)

3.2012 酒精依賴症候群的神經學併發症及醫療花費 (兩年期)

4.2012 延長血栓溶劑治療急性神經不全疾病(多國) EXTEND (International)

5.2012 受試者發生急性缺血性中風後3-6小時內接受懷特血寶注射劑的隨機、雙盲、安慰劑對照試驗 (Pass)

6.2013 隨機分配、雙盲、安慰劑對照、平行組別、為期12個月以Leuco-methylthioninum bis(hydromethanesulfonate)治療輕度至中度阿茲海默症患者之臨床試驗 (多國)

7.2013 NSC 102-2314-B-385-001-降血壓與降血脂藥物對巴金森氏病的風險研究

8.2013 以一隨機、雙盲多中心臨床研究,針對缺血性中風復原,比較併用BNG-1及Aspirin與單獨使用Aspirin之功能性結果與安全性

9.2013 非瓣膜性心房纖維顫動患者併有中風或暫時性腦缺血發作病史服用 Dabigatran 之多中心登錄研究–非介入性、觀察性研究 (多國)

10.2014 台灣中風登錄

11.2014 乙醯膽鹼酶抑制劑的持續使用是否能降低阿茲海默失智症患者的死亡率與醫療費用?-以台灣人口為基礎的研究

12.2015 以磁量阿茲海默症免疫磁減量檢測試劑偵測阿茲海默症患者或因阿茲海默症導致輕度知能障礙患者血漿生物標記的臨床診斷確效評估試驗

13.2015 腦中風急性期之頭部擺位研究 (多國)

14.2015 一個隨機、雙盲、多國多中心的試驗,比較Ticagrelor與阿斯匹靈(ASA)對於罹患急性缺血性腦中風或短暫性腦缺血發作之患者,其預防重大血管事件的效果。[SOCRATES –以阿斯匹靈或Ticagrelor治療急性中風及短暫性腦缺血發作及病患結果 (多國)

15.2015比較Tenecteplase (TNK)與Alteplase (t-PA)在中風血栓溶解效果的臨床試驗 (多國)

16.2016開發應用基因篩檢以預防常見癲癇藥物癲能停(phenytoin)引發之致命過敏反應

 

(二) 2011年至2013年,受行政院衛生署(現衛服部)委託研究計畫調查台灣的失智症流行病學,研究團隊分工完成計劃,負責研究設計,資料的統計分析及論文的撰寫,研究結果發表在2014年的國際期刊。這是我國首次針對全國失智症的大規模本土調查,所得到的各年齡層失智症盛行率的數據,可作為國內未來在老人人口的照顧規劃及長照政策的依據。

 

(三)近五年申請國科會計劃總主持人

2013-2014年降血壓與降血脂藥物對巴金森氏病的風險研究(102-2314-B-385-001-)

2014-2016年創傷性腦損傷與巴金森氏病共病症之長期追蹤研究(103-2314-B-227-002-MY2)

 

(四)

2016~迄今 臨床試驗:UNSV203-AD多國多中心臨床試驗藥物資料安全監測委員會(DSMB)主席

2016~迄今 臨床試驗:RGN1016多中心臨床試驗藥物資料安全監測委員會(DSMB)委員

 

 

(五)特殊醫療服務與著作

1.2012至2013支援偏遠山區醫療

 

2.Homocysteine and vascular diseases (博士論文) 2009

著作

 發表於國際期刊的研究論文

1.       Lee CY, Sun Y, Lee HJ, Chen TF, Wang PN, Lin KN, Tang LY, Lin CC, Chiu, MJ. Modest overweight and healthy dietary habits reduce risk of dementia: a nationwide survey in Taiwan. J Prev Alz Dis 2017;1:37-43.

2.       Hou WH, Li CY, Chang HH, Sun Y, Tsai CC. A population-based cohort study suggests an increased risk of multiple sclerosis incidence in patients with type 2 diabetes mellitus. J Epidemiol 2017 Jan 27.

3.       Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH. Association Between Zolpidem and Suicide: A Nationwide Population-Based Case-Control Study. Mayo Clin Proc 2016 Jan 6.

4.       Liu CC, Li CY, Lee PC, Sun Y. Variations in Incidence and Prevalence of Parkinson's Disease in Taiwan: A Population-Based Nationwide Study. Parkinsons Dis 2016;2016:8756359.

5.       Sun Y, Lu CJ, Chen RC, Hou WH, Li CY. Risk of Amyotrophic Lateral Sclerosis in Patients With Diabetes: A Nationwide Population-Based Cohort Study. J Epidemiol 2015 Jun 5;25:445-51.

6.       Jeng JS, Sun Y, Lee JT, Lin RT, Chen CH, Po HL, Lin HJ, Liu CH, Sun MH, Sun MC, Chern CM, Lien LM, Chiu HC, Hu HH, Chiou HY, Chen ST, Ma H, Hsu CY. The efficacy and safety of cilostazol in ischemic stroke patients with peripheral arterial disease (SPAD): protocol of a randomized, double-blind, placebo-controlled multicenter trial. Int J Stroke 2015 Jan;10:123-7.

7.       Fan LY, Sun Y, Lee HJ, Yang SC, Chen TF, Lin KN, Lin CC, Wang PN, Tang LY, Chiu MJ. Marital Status, Lifestyle and Dementia: A Nationwide Survey in Taiwan. PLoS One 2015;10:e0139154.

8.       Sun Y, Lee HJ, Yang SC, Chen TF, Lin KN, Lin CC, Wang PN, Tang LY, Chiu MJ. A nationwide survey of mild cognitive impairment and dementia, including very mild dementia, in Taiwan. PLoS One 2014;9:e100303.

9.       Lu CJ, Sun Y, Muo CH, Chen RC, Chen PC, Hsu CY. Risk of Stroke with Thiazolidinediones: A Ten-Year Nationwide Population-Based Cohort Study. Cerebrovasc Dis 2013;36:145-51.

10.     Huang HL, Kuo LM, Chen YS, Liang J, Chiu YC, Chen ST, Sun Y, Hsu WC, Shyu YI. A home-based training program improves caregivers' skills and dementia patients' aggressive behaviors: a randomized controlled trial. Am J Geriatr Psychiatry 2013 Nov;21:1060-70.

11.     Chan HF, Sun Y, Lin CH, Chen RC. Madelung's disease associated with polyneuropathy and symptomatic hypokalemia. J Formos Med Assoc 2013 May;112:283-6.

12.     Sun Y, Chang YH, Chen HF, Su YH, Su HF, Li CY. Risk of Parkinson Disease Onset in Patients With Diabetes: A 9-year population-based cohort study with age and sex stratifications. Diabetes Care 2012 May;35:1047-9.

13.     Hong CT, Sun Y, Lu CJ, Shin HC, Chen RC. Prediction of infarct growth and neurologic deterioration in patients with positive perfusion-diffusion mismatch. Clin Neurol Neurosurg 2012 May;114:376-80.

14.     Chen SY, Chen TF, Lai LC, Chen JH, Sun Y, Wen LL, Yip PK, Chu YM, Chen YC. Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease. J Neuroinflammation 2012;9:21.

15.     Lin KP, Chen SY, Lai LC, Huang YL, Chen JH, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen WJ, Chen YC. Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease. PLoS One 2011;6:e20573.

16.     Sun Y, Lu CJ, Chen RC, Chien KL. Lack of association between total serum homocysteine and extracranial cerebral flow. J Formos Med Assoc 2010 Apr;109:278-86.

17.     Lu CJ, Sun Y, Chen SS. Incidence of Creutzfeldt-Jakob disease in Taiwan: a prospective 10-year surveillance. Eur J Epidemiol 2010 May;25:341-7.

18.     Sun Y CT, Chi-Hsin Huang Taiwan Stroke Registry Investigators. A New score to screen peripheral artery disease in patients with ischemic stroke. International Symposium on Peripheral Arterial Disease in Stroke Patients 2009.

19.     Sun Y, Lu CJ, Lin CH, Wen LL. Interleukin-1beta is increased in the cerebrospinal fluid of patients with small infarcts. Eur J Neurol 2009 Jul;16:858-63.

20.     Sun Y, Chien KL, Hsu HC, Su TC, Chen MF, Lee YT. Use of serum homocysteine to predict stroke, coronary heart disease and death in ethnic Chinese. 12-year prospective cohort study. Circ J 2009 Aug;73:1423-30.

21.     Chan KF LC, Kuo BJ, Sun Y. Association between Autonomic Function and Stroke Onset in Sleep. Taiwan Neurological Society Annual Meeting 2009.

22.     Sun Y, Lai MS, Lu CJ, Chen RC. How long can patients with mild or moderate Alzheimer's dementia maintain both the cognition and the therapy of cholinesterase inhibitors: a national population-based study. Eur J Neurol 2008 Mar;15:278-83.

23.     Lu CJ, Sun Y, Lin CH, Huang CC, Liu CH, Chen RC. Use of baseline NIH Stroke Scale and Glasgow Coma Scale as predictors of 30-day functional outcome and mortality after ischemic stroke. Taiwan Stroke Society Annual Meeting 2008.

24.     Hong CT, Sun Y, Lu CJ. Fatal intoxication using amantadine and pramipexole in a uremic patient. Acta Neurol Taiwan 2008 Jun;17:109-11.

25.     Sun Y, Lu CJ, Chien KL, Chen ST, Chen RC. Efficacy of multivitamin supplementation containing vitamins B6 and B12 and folic acid as adjunctive treatment with a cholinesterase inhibitor in Alzheimer's disease: a 26-week, randomized, double-blind, placebo-controlled study in Taiwanese patients. Clin Ther 2007 Oct;29:2204-14.

26.     Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan 2005 Jun;14:48-54.

27.     Lu CJ, Kao HL, Sun Y, Liu HM, Jeng JS, Yip PK, Lee YT. The hemodynamic effects of internal carotid artery stenting: a study with color-coded duplex sonography. Cerebrovasc Dis 2003;15:264-9.

28.     Lu CJ, Kao HL, Sun Y, Liu HM, Jeng JS, Yip PK. Postprocedural complications after angioplasty with stenting of the internal carotid artery. Cerebrovasc Dis 2003;16:308-10.

29.     Sun Y, Lin CH, Lu CJ, Yip PK, Chen RC. Carotid atherosclerosis, intima media thickness and risk factors--an analysis of 1781 asymptomatic subjects in Taiwan. Atherosclerosis 2002 Sep;164:89-94.

30.     Lu CJ, Sun Y, Jeng JS, Huang KM, Hwang BS, Lin WH, Chen RC, Yip PK. Imaging in the diagnosis and follow-up evaluation of vertebral artery dissection. J Ultrasound Med 2000 Apr;19:263-70.

31.     Lu CJ, Sun Y, Huang KM. Leptomeningeal enhancement after carotid stenting. Stroke 2000 Sep;31:2274-5; author reply 6-7.

32.     Sun Y, Yip PK, Jeng JS, Hwang BS, Lin WH. Ultrasonographic study and long-term follow-up of Takayasu's arteritis. Stroke 1996 Dec;27:2178-82.

33.     Sun Y, Cheng, AL, Chen CL, Huang KM, Wong JM, Chen RC. An early gastric cancer presented with widespread metastasis, disseminated intravascular coagulation, and a fulminant clinical course – to the memory of Dr. Ming-Yau Chung. Acta Neurol Sin 1995;4:8.

 

*註: 2012年糖尿病與巴金森病研究論文發表後,引起國際媒體注意,並接受路透社記者訪問。

More evidence ties diabetes to Parkinson's risk

Wed, Apr 4 2012

… Exactly what it all means is unclear, according to Drs. Yu Sun and Chung-Yi Li, who led the study. … "Our findings tend to suggest a relationship between diabetes and early-onset Parkinson's disease," said Sun and Li, who are based at En Chu Kong Hospital and National Cheng Kung University in Taiwan…”