工作團隊

孫瑜

學歷

1. 臺灣大學預防醫學研究所博士

2. 中國醫藥大學醫學系

 

經歷

1.臺大醫院神經部住院醫師

 

2.臺大醫院神經部總醫師

 

3.羅東博愛醫院主治醫師

 

 

現職

 

1.恩主公醫院神經科主任

2.臺大醫學院醫學系兼任助理教授

3.授課:台大醫學系; 台大復健學系(職能治療/物理治療): 神經科學

4.臺大醫院神經部兼任主治醫師

5.睡眠醫學會專科醫師甄審委員

6.台灣失智症協會學術組委員

 

 

 

 

專長

1. 失智症

2. 睡眠障礙

3. 一般神經醫學

學會/資格/其他

獲獎榮譽

1.   2000 年臺灣神經醫學會壁報優秀論文獎.

2.   第五屆 (2002年) 杜世彬博士紀念論文獎第一名.

3.   2005 年臺灣腦中風醫學會論文獎第二名.

4.  2008 年臺灣神經醫學會壁報優秀論文獎 -- 腦中風組.

5.  2008 年指導住院醫師研究獲臺灣神經醫學會壁報優秀論文獎 -- 神經影像組

6.  2009 腦中風醫學會 PAD and Stroke 國際研討會論文獎第一名

 

獲邀至國內外醫學會年會、國際或全國性專題學術演講

  • 2012臺灣醫學會年會-失智症藥物預防與治療的新進展
  • 2012韓國腦中風學會年會-International Guideline Review in 2nd Stroke prevention
  • 2013 International Conference of Alzheimer’s Disease International-
  • Epidemiological Study of Dementia (Including Mild Cognitive Impairment) in Taiwan
  • 2013台灣公共衛生學會年會-輕度認知功能障礙及失智症盛行率之全國性調查
  • 2014社團法人台灣失智症協會、台灣臨床失智症學會-失智症流行病學調查之研究設計
  • 2014臺灣醫學會春季學術演講會-糖尿病藥物的中風風險
  • 2014台灣腦中風學會年會-High Risk of Stroke Patients with Peripheral Artery Disease in Taiwan
  • 2014香港腦中風學會年會-The Efficacy and Safety of Cilostazol in Ischemic Stroke Patients with Peripheral Arterial Disease
  •  2014台灣神經生理技術學會年會-Sleep related Neurologic Disorders
  • 2016台灣腦中風學會年會-The Best and Worst Case Scenarios in the Stroke Prevention of Atrial Fibrillation
  • 2017全球失智症報告-失智症健康照護路徑的成本

 

參與國際性多國多中心或國內的臨床試驗擔任主持人或共同主持人

1.臨床試驗研究計劃:

  •  2011 Cilostazol用在缺血性腦中風病患合併周邊動脈疾病的療效與安全性 (SPAD)
  • 2012 酒精依賴症候群的神經學併發症及醫療花費 (兩年期)
  • 2012 延長血栓溶劑治療急性神經不全疾病(多國) EXTEND (International)
  • 2012 受試者發生急性缺血性中風後3-6小時內接受懷特血寶注射劑的隨機、雙盲、安慰劑對照試驗 (Pass)
  • 2013 隨機分配、雙盲、安慰劑對照、平行組別、為期12個月以Leuco-methylthioninum bis(hydromethanesulfonate)治療輕度至中度阿茲海默症患者之臨床試驗 (多國)
  • 2013 NSC 102-2314-B-385-001-降血壓與降血脂藥物對巴金森氏病的風險研究
  • 2013 以一隨機、雙盲多中心臨床研究,針對缺血性中風復原,比較併用BNG-1及Aspirin與單獨使用Aspirin之功能性結果與安全性
  • 2013 非瓣膜性心房纖維顫動患者併有中風或暫時性腦缺血發作病史服用 Dabigatran 之多中心登錄研究–非介入性、觀察性研究 (多國)
  • 2014 台灣中風登錄
  • 2014 乙醯膽鹼酶抑制劑的持續使用是否能降低阿茲海默失智症患者的死亡率與醫療費用?-以台灣人口為基礎的研究
  • 2015 以磁量阿茲海默症免疫磁減量檢測試劑偵測阿茲海默症患者或因阿茲海默症導致輕度知能障礙患者血漿生物標記的臨床診斷確效評估試驗
  • 2015 腦中風急性期之頭部擺位研究 (多國)
  • 2015 一個隨機、雙盲、多國多中心的試驗,比較Ticagrelor與阿斯匹靈(ASA)對於罹患急性缺血性腦中風或短暫性腦缺血發作之患者,其預防重大血管事件的效果。[SOCRATES –以阿斯匹靈或Ticagrelor治療急性中風及短暫性腦缺血發作及病患結果 (多國)
  • 2015比較Tenecteplase (TNK)與Alteplase (t-PA)在中風血栓溶解效果的臨床試驗 (多國)
  • 2016開發應用基因篩檢以預防常見癲癇藥物癲能停(phenytoin)引發之致命過敏反應

 

2.科技部專題研究計劃主持人或共同主持人

計劃主持人: 2013-2014 降血壓與降血脂藥物對巴金森氏病的風險研究 (計畫編號:102-2314-B-385-001-)

計劃主持人: 2010-2012 睡眠中自主神經功能與中風之相關性研究 (計畫編號:99-2314-B-385-002-MY2)

計劃主持人: 2003-2004 隨機雙盲方法試驗以維他命複方降低血清中半胱胺酸濃度研究對失智症及阿茲海默症認知功能之改善 (計畫編號: 92-2314-B-385-002-)

共同主持人: 2017-2018 台灣中風臨床試驗聯盟 (計畫編號: 106-2321-B-039-005-)

共同主持人: 2016-2017 台灣中風臨床試驗聯盟 III (計畫編號:105-2325-B-039-003-)

共同主持人: 2014-2016 創傷性腦損傷與巴金森氏病共病症之長期追蹤研究 (計畫編號: 103-2314-B-227-002-MY2)

共同主持人: 2012-2013 以社區為基礎之認知障礙老人的電腦化認知訓練方案之建立與成效的探討 (計畫編號: 101-2314-B-570-001-)

 

3. 衛生福利部委託科技研究計畫:

協同主持人 2011年至2013年 “失智症(含輕度認知功能障礙MCI)流行病學調查及失智症照護研究計畫”。

 

4. 2016~2018 臨床試驗:UNSV203-AD多國多中心臨床試驗藥物資料安全監測委員會(DSMB)主席

2016~2018 臨床試驗:RGN1016多中心臨床試驗藥物資料安全監測委員會(DSMB)委員

著作

 

發表於國際期刊的研究論文 (*通訊作者)

1.    Ku LE, Li CY, Sun Y*. Can Persistence With Cholinesterase Inhibitor Treatment Lower Mortality and Health-Care Costs Among Patients With Alzheimer's Disease? A Population-Based Study in Taiwan. Am J Alzheimers Dis Other Demen 2018 Mar;33:86-92.

2.    Lee CY, Sun Y, Lee HJ, Chen TF, Wang PN, Lin KN, Tang LY, Lin CC, Chiu MJ. Modest Overweight and Healthy Dietary Habits Reduce Risk of Dementia: A Nationwide Survey in Taiwan. J Prev Alzheimers Dis 2017;4:37-43.

3.    Hou WH, Li CY, Chang HH, Sun Y, Tsai CC. A population-based cohort study suggests an increased risk of multiple sclerosis incidence in patients with type 2 diabetes mellitus. J Epidemiol 2017 May;27:235-41.

4.    Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH. Association Between Zolpidem and Suicide: A Nationwide Population-Based Case-Control Study. Mayo Clin Proc 2016 Mar;91:308-15.

5.    Liu CC, Li CY, Lee PC, Sun Y*. Variations in Incidence and Prevalence of Parkinson's Disease in Taiwan: A Population-Based Nationwide Study. Parkinsons Dis 2016;2016:8756359.

6.    Sun Y, Lu CJ, Chen RC, Hou WH, Li CY. Risk of Amyotrophic Lateral Sclerosis in Patients With Diabetes: A Nationwide Population-Based Cohort Study. J Epidemiol 2015 Jun 5;25:445-51.

7.    Jeng JS, Sun Y, Lee JT, Lin RT, Chen CH, Po HL, Lin HJ, Liu CH, Sun MH, Sun MC, Chern CM, Lien LM, Chiu HC, Hu HH, Chiou HY, Chen ST, Ma H, Hsu CY. The efficacy and safety of cilostazol in ischemic stroke patients with peripheral arterial disease (SPAD): protocol of a randomized, double-blind, placebo-controlled multicenter trial. Int J Stroke 2015 Jan;10:123-7.

8.    Fan LY, Sun Y, Lee HJ, Yang SC, Chen TF, Lin KN, Lin CC, Wang PN, Tang LY, Chiu MJ. Marital Status, Lifestyle and Dementia: A Nationwide Survey in Taiwan. PLoS One 2015;10:e0139154.

9.    Sun Y, Lee HJ, Yang SC, Chen TF, Lin KN, Lin CC, Wang PN, Tang LY, Chiu MJ. A nationwide survey of mild cognitive impairment and dementia, including very mild dementia, in Taiwan. PLoS One 2014;9:e100303.

10. Lu CJ, Sun Y*, Muo CH, Chen RC, Chen PC, Hsu CY. Risk of Stroke with Thiazolidinediones: A Ten-Year Nationwide Population-Based Cohort Study. Cerebrovasc Dis 2013;36:145-51.

11. Huang HL, Kuo LM, Chen YS, Liang J, Chiu YC, Chen ST, Sun Y, Hsu WC, Shyu YI. A home-based training program improves caregivers' skills and dementia patients' aggressive behaviors: a randomized controlled trial. Am J Geriatr Psychiatry 2013 Nov;21:1060-70.

12. Chan HF, Sun Y, Lin CH, Chen RC. Madelung's disease associated with polyneuropathy and symptomatic hypokalemia. J Formos Med Assoc 2013 May;112:283-6.

13. Sun Y, Chang YH, Chen HF, Su YH, Su HF, Li CY. Risk of Parkinson Disease Onset in Patients With Diabetes: A 9-year population-based cohort study with age and sex stratifications. Diabetes Care 2012 May;35:1047-9.

14.  Hong CT, Sun Y*, Lu CJ, Shin HC, Chen RC. Prediction of infarct growth and neurologic deterioration in patients with positive perfusion-diffusion mismatch. Clin Neurol Neurosurg 2012 May;114:376-80.

15.  Chen SY, Chen TF, Lai LC, Chen JH, Sun Y, Wen LL, Yip PK, Chu YM, Chen YC. Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease. J Neuroinflammation 2012;9:21.

16.  Lin KP, Chen SY, Lai LC, Huang YL, Chen JH, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen WJ, Chen YC. Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease. PLoS One 2011;6:e20573.

17.  Sun Y, Lu CJ, Chen RC, Chien KL. Lack of association between total serum homocysteine and extracranial cerebral flow. J Formos Med Assoc 2010 Apr;109:278-86.

18.  Lu CJ, Sun Y*, Chen SS. Incidence of Creutzfeldt-Jakob disease in Taiwan: a prospective 10-year surveillance. Eur J Epidemiol 2010 May;25:341-7.

19.  Sun Y, Lu CJ, Lin CH, Wen LL. Interleukin-1beta is increased in the cerebrospinal fluid of patients with small infarcts. Eur J Neurol 2009 Jul;16:858-63.

20.  Sun Y, Chien KL, Hsu HC, Su TC, Chen MF, Lee YT. Use of serum homocysteine to predict stroke, coronary heart disease and death in ethnic Chinese. 12-year prospective cohort study. Circ J 2009 Aug;73:1423-30.

21.  Sun Y, Lai MS, Lu CJ, Chen RC. How long can patients with mild or moderate Alzheimer's dementia maintain both the cognition and the therapy of cholinesterase inhibitors: a national population-based study. Eur J Neurol 2008 Mar;15:278-83.

22.  Hong CT, Sun Y, Lu CJ. Fatal intoxication using amantadine and pramipexole in a uremic patient. Acta Neurol Taiwan 2008 Jun;17:109-11.

23.  Sun Y, Lu CJ, Chien KL, Chen ST, Chen RC. Efficacy of multivitamin supplementation containing vitamins B6 and B12 and folic acid as adjunctive treatment with a cholinesterase inhibitor in Alzheimer's disease: a 26-week, randomized, double-blind, placebo-controlled study in Taiwanese patients. Clin Ther 2007 Oct;29:2204-14.

24.  Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan 2005 Jun;14:48-54.

25.  Lu CJ, Kao HL, Sun Y, Liu HM, Jeng JS, Yip PK, Lee YT. The hemodynamic effects of internal carotid artery stenting: a study with color-coded duplex sonography. Cerebrovasc Dis 2003;15:264-9.

26.  Lu CJ, Kao HL, Sun Y, Liu HM, Jeng JS, Yip PK. Postprocedural complications after angioplasty with stenting of the internal carotid artery. Cerebrovasc Dis 2003;16:308-10.

27.  Sun Y, Lin CH, Lu CJ, Yip PK, Chen RC. Carotid atherosclerosis, intima media thickness and risk factors--an analysis of 1781 asymptomatic subjects in Taiwan. Atherosclerosis 2002 Sep;164:89-94.

28.  Lu CJ, Sun Y, Jeng JS, Huang KM, Hwang BS, Lin WH, Chen RC, Yip PK. Imaging in the diagnosis and follow-up evaluation of vertebral artery dissection. J Ultrasound Med 2000 Apr;19:263-70.

29.  Lu CJ, Sun Y, Huang KM. Leptomeningeal enhancement after carotid stenting. Stroke 2000 Sep;31:2274-5; author reply 6-7.

30.  Sun Y, Yip PK, Jeng JS, Hwang BS, Lin WH. Ultrasonographic study and long-term follow-up of Takayasu's arteritis. Stroke 1996 Dec;27:2178-82.

31.  Sun Y, Cheng AL, Chen CL, Huang KM, Wong JM, Chen RC. An early gastric cancer presented with widespread metastasis, disseminated intravascular coagulation, and a fulminant clinical course – to the memory of Dr. Ming-Yau Chung. Acta Neurol Sin 1995;4:183-90.