Portfolio

• Physician scientist with great interests in personalized medicine
• Mouse biologist experienced in gene knockouts and SNP-based
• studies Board-certified pediatrician and gastroenterologist

The University of Texas Southwestern Medical Center at Dallas

• Ph.D.: Integrative Biology August 2001 - October 2006
  • In silico cloning of a novel muscular gene with BTB-kelch domains and a distinct expression pattern in LacZ-knockin mice
  • B-cell autonomous functions of Klhl6 in mice
  • T-cell autonomous functions of TGFβ-activated kinase 1
• Advisor: Zhijian J. Chen, Ph.D.

National Taiwan University College of Medicine, Taiwan

• MD: School of Medicine August 1989 - June 1996

• National Health Research Institutes
  Assistant Investigator and Attending Physician
  November 2012 - Present
• EnChuKong Hospital
  Attending Physician
  July 2011 - Present
• National Taiwan University Children’s Hospital
  Pediatric Gastroenterology Fellow
  Advisor: Mei-Hwei Chang, M.D.
  July 2011 - June 2012
• Taiwan Adventist Hospital/National Taiwan University Children’s Hospital
  Pediatric Gastroenterology Fellow
  Advisor: Mei-Hwei Chang, M.D.
  July 2010 - June 2011
• Roche Palo Alto/Stanford University
  Postdoctoral Fellow
  Advisor: Gary Peltz, M.D., Ph.D.
  November 2006 - June 2010
• The University of Texas Southwestern Medical Center at Dallas
  Graduate Student
  Advisor: Zhijian J. Chen, Ph.D.
  August 2001 - October 2006
• Pediatrics Department of National Taiwan University Hospital, Taiwan
  Resident
  Chair: Mei-Hwei Chang, M.D.
  June 1998 - June 2001
• Compulsory Military Service, Taiwan
  Army Physician
  July 1996 - May 1998
• National Taiwan University Hospital, Taiwan
  Intern
  July 1995 - June 1996

• En Chu Kong Hospital, Attending Physician, July 2011 - Present

Mouse Genetics

• Conditional and conventional knockout mice
• Hands-on experience in designing knockout constructs, stem cell culture, and colony breeding plus phenotype analysis
• Work with various Cre lines, including CAG::Cre, Cd19::Cre, proximal Lck::Cre, and tamoxifen-inducible CreERT

Immunology

• Functional characterization of innate and adaptive immune cells
• Numerical description at perspectives of complementarity-determining 3 diversities
• Integrated application of hematopoietically humanized mice

Genomic Research

• Immune repertoire profiling and characterization
• SNP-based associations in pharmacogenomics, immunogenomics, and toxicogenomics

Pediatrics

• Board certified Pediatric Gastroenterologist, Taiwan
• Board certified Pediatrician, Taiwan

Computer Skills

• Languages: Objective C/Cocoa, C/C++, Python, OpenCL
• Operating systems: Mac OS X with MacPorts package subsystem, (Debian, Ubuntu) Linux, Windows
• Applications: LATEX 2ε, Emacs, Xcode, Microsoft Office suite, DNA Strider, Django web frame- work

License and Certification

• Board of Gastroenterologist, Taiwan 2012
• Board of Pediatrics, Taiwan 2001
• Medical License, Taiwan 1996

Honor

• EnChuKong Hospital: The Best Working Partner 2015
• Stanford University School of Medicine: The Anesthesia Department Research Award 2010
• National Taiwan University College of Medicine: Honors in Public Service 1996

Patent

• Liu, H.H., G.A. Peltz, G. Liao, and T.A. Garrow. Compositions and methods for reducing the risk of agent-induced liver toxicity, July 5 2012. US20120172324.

• Chung-Hao Huang, Ya-Hui Chang, Chun-Yu Lin, Wen-Hung Wang, Hui-Chung Kuan, Ya-Ju Hsieh, Yu-Wei Wang, Chung-Hsiang Yang, Jhen-Yan Chiu, Shih-Feng Tsai, Yen-Hsu Chen, and Hong-Hsing Liu. Shared IgG infection signatures vs. hemorrhage-restricted IgA clusters in human dengue: A phenotype of differential class-switch via TGFβ1. Frontiers in Immunology, 8:1726, 2017.
• Huey-Huey Chua, Hung-Chieh Chou, Ya-Ling Tung, Bor-Luen Chiang, Chien-Chia Liao, Hong-Hsing Liu, and Yen-Hsuan Ni. Intestinal dysbiosis featuring abundance of ruminococ- cus gnavus associates with allergic diseases in Gastroenterology, 154:154–167, January 2018.
• Ya-Hui Chang^†, Hui-Chung Kuan^†, T. C. Hsieh,   H.  Ma,  Chung-Hsiang  Yang, Wei-Bin Hsu, Shih-Feng Tsai, Anne Chao, and Hong-Hsing Liu. Network signatures of IgG immune repertoires in hepatitis B associated chronic infection and vaccination responses. Sci Rep, 6:26556, 2016. ^†Equal contribution.
• Hong-Hsing Liu, Yajing Hu, Ming Zheng, Megan M. Suhoski, Edgar G. Engleman, David L. Dill, Matt Hudnall, Jianmei Wang, Rosanne Spolski, Warren Leonard, and Gary Peltz. Cd14 SNPs regulate the innate immune response. Mol Immunol, 51(2):112–127, Jun 2012.
• Gary Peltz, Aimee K. Zaas, Ming Zheng, Norma V. Solis, Mason X. Zhang, Hong-Hsing Liu, Yajing Hu, Gayle M. Boxx, Quynh T. Phan, David Dill, and Scott G. Filler. Next- generation computational genetic analysis: Multiple complement alleles control survival after candida albicans infection. Infect Immun, 79(11):4472–4479, Nov
• Zhang, H-H. Liu, P. Weller, M. Zheng, W. Tao, J. Wang, G. Liao, M. Monshouwer, and
• Peltz. In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor. Pharmacogenomics J, 11(1):15–24, Feb 2011.
• Yajing Hu, Deyong Liang, Xiangqi Li, Hong-Hsing Liu, Xun Zhang, Ming Zheng, David Dill, Xiaoyou Shi, Yanli Qiao, David Yeomans, Brendan Carvalho, Martin S Angst, J. David Clark, and Gary Peltz. The role of interleukin-1 in wound part i: Murine in silico and in vitro experimental analysis. Anesth Analg, 111(6):1525–1533, Dec 2010.
• Yajing Hu, Deyong Liang, Xiangqi Li, Hong-Hsing Liu, Xun Zhang, Ming Zheng, David Dill, Xiaoyou Shi, Yanli Qiao, David Yeomans, Brendan Carvalho, Martin S Angst, J. David Clark, and Gary Peltz. The role of interleukin-1 in wound part ii: In vivo and human translational studies. Anesth Analg, 111(6):1534–1542, Dec 2010.
• Hong-Hsing Liu ^†, Peng Lu^†, Yingying Guo, Erin Farrell, Xun Zhang, Ming Zheng, Betty Bosano, Zhaomei Zhang, John Allard, Guochun Liao, Siyu Fu, Jinzhi Chen, Kimberly Dolim, Ayako Kuroda, Janet Cheng, Kevin Welch, Yanzhou Liu, Joseph Pease, Steve A. de Keczer, Mo- hammad Masjdizadeh, Jing-Shan Hu, Paul Weller, Tim Garrow, and Gary Peltz. An integrative genomic analysis identified Bhmt2 as a diet-dependent genetic factor against acetaminophen- induced liver Genome Res, 20:28–35, 2010. ^†Equal contribution.
• Ming Zheng, Steve Shafer, Guochun Liao, Hong-Hsing Liu, and Gary Peltz. Computational genetic mapping in mice: ’the ship has sailed’. Science Translational Medicine, 1:3ps4,
• James Schuman, Yuhong Chen, Andrew Podd, Mei Yu, Hong-Hsing Liu, Renren Wen, Zhi- jian J Chen, and Demin A critical role of TAK1 in B cell receptor-mediated NF-κB activation. Blood, 113(19):4566–4574, May 2009.
• Hong-Hsing Liu, Min Xie, Michael D Schneider, and Zhijian J Chen. Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A, 103(31):11677–11682, Aug
• Qinmiao Sun^†, Lijun Sun^†, Hong-Hsing Liu, Xiang Chen, Rashu B Seth, James Forman, and Zhijian J Chen. The specific and essential role of MAVS in antiviral innate immune responses. Immunity, 24(5):633–642, May 2006. ^†Equal
• Hong-Hsing Liu ^†, Jens Kroll^†, Xiaozhong Shi^†, Arianna Caprioli^†, Claudia Waskow, Keng- Mean Lin, Toru Miyazaki, Hans-Reimer Rodewald, and Thomas N Sato. The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Mol Cell Biol, 25(19):8531–8540, Oct 2005. ^†Equal
• Hong-Hsing Liu, Ming-Tai Lin, Chien-Chih Chang, Jou-Kou Wang, Mei-Hwan Wu, Ming- Kwang Shyu, Chien-Nan Lee, and Fon-Jou Postnatal outcome of fetal cardiac echogenic foci. J Formos Med Assoc, 101(5):329–336, May 2002.
• Hong-Hsing Liu, Wuh-Liang Hwu, Chainllie Young, Wang-Tso Lee, Jyh-Chou Yang, Muh- Shy Chen, and Yu-Zen   Phenotypic polymorphism associated with the T8993G mutation  of the mitochondrial ATPase6 gene in a family. Acta Paediatrica Sinica, 40(1):126–126, April 1999.
• Hong-Hsing Liu ^†. Current Diagnosis & Treatment. Current Medicine, ING. (Chinese Ver- sion); Churchill Livingstone (English Version), Roy Pounder and Mark Hamilton edition, ISBN: 957-666-554-X ^†Translator for Chinese Version.

Institute of Molecular and Genomic Medicine

• National Health Research Institutes, Zhunan Town, Miaoli County 35053, Taiwan
• Office: +886-37-246166 ext 35398
• Fax: +886-37-586459
• E-mail: hhliu@nhri.org.tw

Pediatrics

• EnChuKong Hospital, Sanxia District, New Taipei City 23702, Taiwan
• Office: +886-2-26723456
• Fax: +886-2-86710550
• E-mail: honghsing.liu@gmail.com